Normal Dendritic Cell Mobilization to Lymph Nodes under Conditions of Severe Lymphatic Hypoplasia

Lymphatic Hypoplasia Lymph Nodes under Conditions of Severe Normal Dendritic Cell Mobilization to

Dendritic cell migration to peripheral lymph nodes.

Dendritic cells are potent antigen-presenting cells endowed with the unique ability to prime T-cell responses. To present foreign antigens to na ive T cells, dendritic cells must migrate from inflamed or injured peripheral tissues to the closest draining lymph nodes through afferent lymphatic vessels. In addition, conventional dendritic cells, plasmacytoid dendritic cells and monocytes enter ly...

Obesity Impairs Lymphatic Fluid Transport and Dendritic Cell Migration to Lymph Nodes

INTRODUCTION Obesity is a major cause of morbidity and mortality resulting in pathologic changes in virtually every organ system. Although the cardiovascular system has been a focus of intense study, the effects of obesity on the lymphatic system remain essentially unknown. The purpose of this study was to identify the pathologic consequences of diet induced obesity (DIO) on the lymphatic syste...

Sphingosine-1-phosphate receptor type-1 agonism impairs blood dendritic cell chemotaxis and skin dendritic cell migration to lymph nodes under inflammatory conditions.

SEW2871 is a potent sphingosine-1-phosphate receptor type-1 (S1P(1))-selective agonist that induces peripheral lymphopenia through sequestration of lymphocytes into secondary lymphoid organs, similar to the non-selective sphingosine-1-phosphate (S1P) receptor agonist FTY720. FTY720 has been reported to interfere with human dendritic cell (DC) effector functions and both FTY720 and SEW2871 have ...

Sonography of neck lymph nodes. Part I: normal lymph nodes.

Grey scale and power Doppler sonography play an important role in assessment of cervical lymphadenopathy. However, before examination of pathological nodes, a clear understanding of the anatomy of cervical nodes, scanning technique and sonographic appearances of normal cervical nodes is essential. This article reviews these topics in order to provide a baseline for sonographic examination of ce...